Publications

White papers

 

Epigenetic status of argininosuccinate synthetase and argininosuccinate lyase modulates autophagy and cell death in glioblastoma

Citation: Cell Death and Disease (2013) 4, e458; doi:10.1038/cddis.2012.197 & 2013 Macmillan Publishers Limited All rights reserved 2041-4889/13

N Syed*,1, J Langer1, K Janczar1, P Singh1, C Lo Nigro2, L Lattanzio2, HM Coley3, E Hatzimichael4, J Bomalaski5, P Szlosarek6, M Awad7, K O’Neil 7, F Roncaroli1 and T Crook8

 

 

Proteasome inhibition in cancer is associated with enhanced tumor targeting by the adeno-associated virus/phage

Molecular Oncology XXX (2012) 1-12 August 01, 2012  Justyna M. Przystal a,1, Eloho Umukoro a,1, Charlotte A. Stoneham a, Teerapong Yata a, Kevin O’Neill b, Nelofer Syed b, Amin Hajitou a

  1. a Division of Brain Sciences, Hammersmith Hospital Campus, Department of Medicine, Imperial College London, Burlington Danes Building, 160 Du Cane Road, London W12 0NN, United Kingdom
  2. b Division of Brain Sciences, Charing Cross Campus, Department of Medicine, Imperial College London, London, United Kingdom

Intra-operative, real-time, three-dimensional ultrasound assisted positioning of catheters in the microdialysis of glial tumours Journal of Clinical Neuroscience 2010, doi:10.1016/j.jocn.2009.06.022.  Bob Homapour a, Jonathan E. Bowen b, Elizabeth J. Want b, Kevin O’Neill a, Vasileios Apostolopoulos a, Dipankar Nandi a, James R. Van Dellen a, Federico Roncaroli a,*

  1. a Department of Clinical Neuroscience, Division of Neuroscience and Mental Health, Imperial College, Imperial Healthcare NHS Trust and BTRC Research Group, Charing Cross Campus, St Dunstans Road, London W6 8RP, UK
  2. b Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Imperial College, London, UK

Site-specific CpG methylation in the CCAAT/enhancer binding protein delta (CEBPδ) CpGisland in breast cancer is associated with metastatic relapse.  Palmieri C, Monteverde M, Lattanzio L, Gojis O, Rudraraju B, Fortunato M, Syed N, Thompson A, Garrone O, Merlano M, Lo Nigro C, CrookT. Br J Cancer. 2012 Jul 10

NT5E CpG island methylation is a favourable breast cancer biomarker.  Lo Nigro C, Monteverde M, Lee S, Lattanzio L, Vivenza D, Comino A, Syed N, McHugh A, Wang H, Proby C, Garrone O, Merlano M, Hatzimichael E, Briasoulis E, Gojis O, Palmieri C, Jordan L, Quinlan P, Thompson A, Crook T. Br J Cancer. 2012 Jun 26;107(1):75-83.

Methylation of the calcium channel regulatory subunit α2δ-3 (CACNA2D3) predicts site-specific relapse in oestrogen receptor-positive primary breast carcinomas.  Palmieri C, Rudraraju B, Monteverde M, Lattanzio L, Gojis O, Brizio R, Garrone O, Merlano M, Syed N, Lo Nigro C, Crook T. Br J Cancer. 2012 Jul 10;107(2):375-81.

NT5E (CD73) is epigenetically regulated in malignant melanoma and associated with metastatic site specificity.  Wang H, Lee S, Nigro CL, Lattanzio L, Merlano M, Monteverde M, Matin R, Purdie K, Mladkova N, Bergamaschi D, Harwood C, Syed N, Szlosarek P, Briasoulis E, McHugh A, Thompson A, Evans A, Leigh I, Fleming C, Inman GJ, Hatzimichael E, Proby C, CrookT. Br J Cancer. 2012 Apr 10;106(8):1446-52.

High frequency of complex TP53 mutations in CNS metastases from breast cancer.  Lo Nigro C, Vivenza D, Monteverde M, Lattanzio L, Gojis O, Garrone O, Comino A, Merlano M, Quinlan PR, Syed N, Purdie CA, Thompson A, Palmieri C, CrookT. Br J Cancer. 2012 Jan 17;106(2):397-404.

Intraosseous Angiolipoma of the Cranium: Case Report  Published in Neurosurgery Volume 64 Number 1 January 2009  Kenny Yu, M.D., James Van Dellen, M.D., Philip Idaewor, M.D., Federico Roncaroli, M.D.

Galectin-3 Expression is Ubiquitous in Tumors of the Sellar Region, Nervous System, and Mimics. An Immunohistochemical and RT-PCR Study  Published in American Journal of Surgery and Pathology, Volume 00, Number 00, 2008Fausto J. Rodriguez, MD, Bernd W. Scheithauer, MD, Federico Roncaroli, MD,
Ana I. Silva, MD, Kalman Kovacs, MD, PhD, Daniel J. Brat, MD, PhD, and Long Jin, MD

Papillary Tumor of the Pineal Region and Spindle Cell Oncocytoma of the Pituitary: New Tumor Entities in the 2007 WHO Classification  Published in Brain Pathology; issue 17:314–318, 2007  Federico Roncaroli, University Department of Neuropathology, Imperial College, London, UK. Bernd W. Scheithauer, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.

The Peripheral Benzodiazepine Receptor (PBR) in Gliomas  Received: 26 January 2007 / Accepted: 23 April 2007
Springer Science+Business Media B.V. 2007  Shigetoshi Takaya, Kazuo Hashikawa, Federico E. Turkheimer, Nicholas Mottram, Manuel Deprez, Koichi Ishizu, Hidekazu Kawashima, Haruhiko Akiyama, Hidenao Fukuyama, Richard B. Banati, Federico Roncaroli

Cerebellar Astroblastoma  Published in Brain Pathology; issue 17(2):251-252, 2007  Iqroop Chopra, MD MRCS; Federico Roncaroli, MD1; Vasileios Apostolopoulos, MD MRCS; Jilly Moss, FRCPath2; David Peston, FIBMS2; Kevin O’Neill, MD FRCS, FRCS-SN

Treatment of Newly Diagnosed Glioblastoma with Concomitant and Adjuvant Temozolomide and Radiotherapy  Published in American Journal of Cancer 2006; 5 (6): 427-432  Mark J. Beresford, Danielle Power, Emma Alexander, Cathryn Brock, Julian Thompson, Federico Roncaroli, Adam D. Waldman, James van Dellen and Mark Glaser

Chromosomal Patterns of Gene Expression from Microarray Data: Methodology, Validation and Clinical Relevance in Gliomas  Published in BMC Bioinformatics 2006, 7:526 http://www.biomedcentral.com/1471-2105/7/526  Federico E Turkheimer, Federico Roncaroli, Benoit Hennuy, Christian Herens, Minh Nguyen, Didier Martin, Annick Evrard, Vincent Bours, Jacques Boniver and Manuel Deprez

Microglia in Gemistocytic Astrocytomas  Published in Neurosurgery Volume 60 Number 1 January 2007F. Geranmayeh, B.Sc., M.B.B.S., B.W. Scheithauer, M.D., C. Spitzer, M.D., F.B. Meyer, M.D., A.C. Svensson-Engwall, Ph.D., Manuel B. Graeber, M.D., Ph.D.

 

Abstracts

Sonowand project item 1. Sonowand project: The safety and feasibility of intraoperative ultrasound to aid intrinsic tumour resection: a retrospective case-control series.  Cameron Smail R, Brown A, Baldwin M, O’Neill KS

Sonowand project item 2.  The safety and feasibility of intraoperative ultrasound to aid intrinsic tumour resection: a retrospective case-control series.  Cameron Smail R, Brown A, Baldwin M, O’Neill KS

Dual systemic tumour targeting with ligand-directed phage and Grp78 promoter induces regression of glioblastoma. Dr. Amin Hajitou.  NB This abstract won the “Best Scientific Abstract award at the 2012 British Neuro-oncology Society’s 2012 Annual Conference

Transcriptional silencing disrupts two levels of arginine biosynthesis in glioblastoma multiforme (GBM): a novel, targeted therapeutic strategy for GBM  N Syed, F Roncaroli, K Janczar, P Singh, K O’Neil, C Lo Nigro, L Lattanzio, HM Coley, E Hatzimichael, J Bomalaski, P Szlosarek, T Crook.  British Neuro-oncology Society:  Abstract submission 2012

Transcriptional silencing disprupts two levels of arginine biosynthesis in glioblastoma multiforme: a novel targeted therapeutic strategy for high grade gliomas.  Nelofer Syed1; Kevin O’Neill1; Mark Hughes1; Christiana LoNigro2; Laura Lattanzio2; Peter Szlosarek3; Federico Roncaroli1; Timothy Crook1.  1’John Fulcher’ Molecular Neuro-oncology Laboratory, BTRC, Imperial College, London, UK, 2Laboratorio Oncologia Translazionale, Cuneo, Italy, 3 Queen Mary University of London, Institute of Cancer and CR-UK Clinical Centre, Barts and The London School of Medicine, London

Endogenous Cortisol Biosynthesis in Human Gliomas  Presented April 2008 at the American Association of Cancer Research conference in San Diego  Karolina Janczar, Emilie Croisier, Bob Homapour, Kevin O’Neill, Amanda Forsyth, Federico Turkhemier, Manuel Deprez, Federico Roncaroli. BTRC / Imperial College of London, London, United Kingdom & Department of Neuropathology, University of Liege, Belgium